Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study.

@article{So2011UncoveringTT,
  title={Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study.},
  author={H C So and Miaoxin Li and Pak C. Sham},
  journal={Genetic epidemiology},
  year={2011},
  volume={35 6},
  pages={447-56}
}
Genome-wide association studies (GWAS) have become increasingly popular recently and contributed to the discovery of many susceptibility variants. However, a large proportion of the heritability still remained unexplained. This observation raises queries regarding the ability of GWAS to uncover the genetic basis of complex diseases. In this study, we propose a simple and fast statistical framework to estimate the total heritability explained by all true susceptibility variants in a GWAS. It is… CONTINUE READING