Uncovering the role of VDAC in the regulation of cell life and death.

@article{ShoshanBarmatz2008UncoveringTR,
  title={Uncovering the role of VDAC in the regulation of cell life and death.},
  author={Varda Shoshan-Barmatz and Nurit Keinan and Hilal Zaid},
  journal={Journal of bioenergetics and biomembranes},
  year={2008},
  volume={40 3},
  pages={183-91}
}
Proper cell activity requires an efficient exchange of molecules between mitochondria and cytoplasm. Lying in the outer mitochondrial membrane, VDAC assumes a crucial position in the cell, forming the main interface between the mitochondrial and the cellular metabolisms. As such, it has been recognized that VDAC plays a crucial role in regulating the metabolic and energetic functions of mitochondria. Indeed, down-regulation of VDAC1 expression by shRNA leads to a decrease in energy production… CONTINUE READING

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