Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset

Abstract

Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor suppressor. Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this affects DNA replication dynamics while contributing to genomic instability and tumorigenesis. We find that Cdh1 depletion causes early S-phase onset in conjunction with increase in Rb/E2F1… (More)
DOI: 10.1091/mbc.E13-08-0480

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