Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.

@article{Arnedo2015UncoveringTH,
  title={Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.},
  author={J. Arnedo and D. Svrakic and C. Del Val and R. Romero-Z{\'a}liz and Helena Hern{\'a}ndez-Cuervo and A. Fanous and M. Pato and C. Pato and G. D. de Erausquin and C. R. Cloninger and I. Zwir},
  journal={The American journal of psychiatry},
  year={2015},
  volume={172 2},
  pages={
          139-53
        }
}
OBJECTIVE The authors sought to demonstrate that schizophrenia is a heterogeneous group of heritable disorders caused by different genotypic networks that cause distinct clinical syndromes. METHOD In a large genome-wide association study of cases with schizophrenia and controls, the authors first identified sets of interacting single-nucleotide polymorphisms (SNPs) that cluster within particular individuals (SNP sets) regardless of clinical status. Second, they examined the risk of… Expand
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