Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells

@inproceedings{Veiseh2015UncoveringTD,
  title={Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells},
  author={Mandana Veiseh and Sean J. Leith and Cornelia Tolg and Sallie S. Elhayek and S. Bahram Bahrami and Lisa Collis and Sara Rae Hamilton and James B. McCarthy and Mina J. Bissell and Eva Ann Turley},
  booktitle={Front. Cell Dev. Biol.},
  year={2015}
}
The interaction of hyaluronan (HA) with mesenchymal progenitor cells impacts trafficking and fate after tissue colonization during wound repair and these events contribute to diseases such as cancer. How this interaction occurs is poorly understood. Using 10T½ cells as a mesenchymal progenitor model and fluorescent (F-HA) or gold-labeled HA (G-HA) polymers, we studied the role of two HA receptors, RHAMM and CD44, in HA binding and uptake in non-adherent and adherent mesenchymal progenitor (10T… CONTINUE READING
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