Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration

@inproceedings{Kohler2013UncoveringTC,
  title={Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration},
  author={J{\'u}lia Benini Kohler and Cvetan Popov and Barbara Klotz and Paolo Alberton and Wolf Christian Prall and Florian Haasters and Sigrid M{\"u}ller-Deubert and Regina Ebert and L. Klein Hitpass and Franz M Jakob and Matthias Schieker and Denitsa Docheva},
  booktitle={Aging cell},
  year={2013}
}
Although the link between altered stem cell properties and tissue aging has been recognized, the molecular and cellular processes of tendon aging have not been elucidated. As tendons contain stem/progenitor cells (TSPC), we investigated whether the molecular and cellular attributes of TSPC alter during tendon aging and degeneration. Comparing TSPC derived from young/healthy (Y-TSPC) and aged/degenerated human Achilles tendon biopsies (A-TSPC), we observed that A-TSPC exhibit a profound self… CONTINUE READING
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