Uncovering the V(D)J recombinase

@article{Schatz2004UncoveringTV,
  title={Uncovering the V(D)J recombinase},
  author={David G Schatz and David Baltimore},
  journal={Cell},
  year={2004},
  volume={116},
  pages={S103-S108}
}
AS any good high school student can tell you, normal developmental processes give rise to individuals in which each cell contains an identical copy of the genome present in the original, fertilized egg. This comfortable image of a static and inviolate genetic blueprint was shattered in the late 1970s, however, when Susumu Tonegawa and colleagues showed that the genes that encode immunoglobulin heavy and light chains have a different structure in embryonic cells from that found in tumors derived… CONTINUE READING
16 Citations
19 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

The role of DNA breaks in genomic instability and tumorigenesis

  • K. D. Mills, D. O. Ferguson, F. W. AIt
  • Immunol. Rev
  • 2003
1 Excerpt

Similar Papers

Loading similar papers…