Uncovering the Role of Oxidative Imbalance in the Development and Progression of Bronchial Asthma

@article{Vasconcelos2021UncoveringTR,
  title={Uncovering the Role of Oxidative Imbalance in the Development and Progression of Bronchial Asthma},
  author={Luiz Henrique C Vasconcelos and Sarah R D Ferreira and Maria da C C Silva and Paula Benvindo Ferreira and Iara Le{\~a}o Luna de Souza and Fabiana de Andrade Cavalcante and Bagn{\'o}lia Ara{\'u}jo da Silva},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2021},
  volume={2021}
}
Asthma is a chronic inflammatory disease of the airways related to epithelial damage, bronchial hyperresponsiveness to contractile agents, tissue remodeling, and luminal narrowing. Currently, there are many data about the pathophysiology of asthma; however, a new aspect has emerged related to the influence of reactive oxygen and nitrogen species (ROS and RNS) on the origin of this disease. Several studies have shown that an imbalance between the production of ROS and RNS and the antioxidant… 

Figures and Tables from this paper

Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma

The review provides a detailed insight into the therapeutic role of nutraceuticals as an effective strategy to attenuate the deleterious effects of oxidative stress and may be used in the mitigation of the cardinal features of bronchial asthma.

Involvement of Cu-containing amine oxidases in the development of lung pathology in ovalbumin-induced bronchial asthma in guinea pigs

The data obtained indicate the direct participation of the studied enzymes in the progression of pathological processes in atopic bronchial asthma as well as the potential use of semicarbazide as a drug in complex anti-asthmatic therapy.

Vitamin D has an effect on airway inflammation and Th17/Treg balance in asthmatic mice

In conclusion, vitamin D rectified the Th17/Treg balance and alleviated airway inflammation by inhibiting the NF‐κB pathway in asthmatic mice.

An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches

How the expression of Keap1-Nrf2 functions in different respiratory diseases is described and the protective effects of reversing this expression are explained.

Intermittent Hypoxia-Hyperoxia and Oxidative Stress in Developing Human Airway Smooth Muscle

Developing airway smooth muscle is differentially responsive to hypoxic, hyperoxic, or intermittent hypoxic-hyperoxic exposure in terms of mitochondrial structure and function, showing the necessity of balancing oxidative damage and antioxidant defense systems in the developing airway.

Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium

The current studies were focused on the phytochemical profiling of two local wild Artemisia species, Artemisia scoparia and Artemisia absinthium leaves’ essential oils, extracted via the hydro

Follow-up of patients with a 5-year survival after paraquat poisoning using computed tomography images and spirometry.

In the long-term follow-up, patients with severe paraquat poisoning showed the lowest exercise endurance, and CT images revealed diversified changes, not only dynamic evolution of pulmonary fibrosis process, but also signs of bronchiectasis, and chronic obstructive pulmonary disease.

Asthma attacks: Patients who survived paraquat poisoning.

It is considered that patients with acute paraquat (PQ) poisoning may develop asthma in the long term.

Oxidative and nitrative stress in bronchial asthma.

The rapidly accruing data linking oxidative and nitrative events to the pathogenesis of bronchial asthma is described, with increasing evidence that endogenous or exogenous reactive oxygen species and reactive nitrogen species are responsible for the airway inflammation.

Molecular characterization of redox mechanisms in allergic asthma.

Epithelial function and dysfunction in asthma

  • M. LoxhamD. DaviesC. Blume
  • Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2014
A detailed understanding of the regulatory role of the airway epithelium is required to develop new therapeutic strategies for asthma that not only address the symptoms but also the underlining pathogenic mechanism(s) and prevent airway remodelling.

Oxidative stress in airway diseases.

  • F. Holguin
  • Biology
    Annals of the American Thoracic Society
  • 2013
The therapeutic potential of antioxidants could be greatly improved by taking an approach that considers individual and environmental risk factors, instead of treating oxidative airway stress broadly.

Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets.

  • I. Rahman
  • Biology
    Current drug targets. Inflammation and allergy
  • 2002
Effective wide spectrum antioxidant therapy that has good bioavailability and potency is urgently needed to control the localised oxidative and inflammatory processes that occur in the pathogenesis of asthma and COPD.

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

The proposed concept of “multilevel cycle” helps understand the relationship between respiratory diseases and oxidative stress, thus clarifying the rationale for using NAC in COPD.

Oxidative stress in asthma: a distinct clinical and pathologic feature?

  • Y. LiG. Li
  • Biology, Medicine
    Journal of biological regulators and homeostatic agents
  • 2016
Oxidative stress-induced corticosteroid insensitivity was associated with p38 MAPK, PI3K/Akt and Nrf2 signaling, and inhibited histone deacetylase 2 (HDAC2) activity and cortiosteroid receptor (GR) function, suggesting antioxidant treatments may be useful for oxidative stress in asthma.

Oxidative Stress Markers in Sputum

  • B. Antus
  • Biology, Medicine
    Oxidative medicine and cellular longevity
  • 2016
Collectively, even though there are promising findings in this field, further clinical studies using more established detection techniques are needed to clearly show the benefit of these measurements in the follow-up of patients with inflammatory airway diseases.
...