Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster

@inproceedings{Rahbar2017UncoveringTD,
  title={Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster},
  author={Elaheh Rahbar and Hannah C. Ainsworth and Timothy D. Howard and Gregory A Hawkins and Ingo Ruczinski and Rasika A. Mathias and Michael C. Seeds and Susan Sergeant and James E. Hixson and David M. Herrington and Carl D. Langefeld and Floyd H. Chilton},
  booktitle={PloS one},
  year={2017}
}
Genetic variants near and within the fatty acid desaturase (FADS) cluster are associated with polyunsaturated fatty acid (PUFA) biosynthesis, levels of several disease biomarkers and risk of human disease. However, determining the functional mechanisms by which these genetic variants impact PUFA levels remains a challenge. Utilizing an Illumina 450K array, we previously reported strong allele-specific methylation (ASM) associations (p = 2.69×10-29) between a single nucleotide polymorphism (SNP… CONTINUE READING

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