Uncovering novel targets for cancer chemoprevention.

  title={Uncovering novel targets for cancer chemoprevention.},
  author={Konstantin H. Dragnev and Qing Feng and Yan Ma and Sumit J. Shah and Candice C Black and Vincent A. Memoli and William C. Nugent and James R. Rigas and Sutisak Kitareewan and Sarah J. Freemantle and Ethan Dmitrovsky},
  journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer},
Tobacco carcinogen treatment of immortalized human bronchial epithelial (HBE) cells has uncovered novel targets for cancer chemoprevention. Experiments were conducted with HBE cells and independent treatments with tobacco carcinogens along with the chemopreventive agent all-trans-retinoic acid (RA). That work highlighted D-type and E-type cyclins as novel molecular pharmacologic targets of several chemopreventive agents. G1 cyclins are often aberrantly expressed in bronchial preneoplasia and… CONTINUE READING