Uncovering new metabolic capabilities of Bacillus subtilis using phenotype profiling of rifampin-resistant rpoB mutants.

@article{Perkins2008UncoveringNM,
  title={Uncovering new metabolic capabilities of Bacillus subtilis using phenotype profiling of rifampin-resistant rpoB mutants.},
  author={Amy E Perkins and Wayne Nicholson},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 3},
  pages={807-14}
}
RNA polymerase is a central macromolecular machine controlling the flow of information from genotype to phenotype, and insights into global transcriptional regulation can be gained by studying mutational perturbations in the enzyme. Mutations in the RNA polymerase beta subunit gene rpoB causing resistance to rifampin (Rif(r)) in Bacillus subtilis were previously shown to lead to alterations in the expression of a number of global phenotypes known to be under transcriptional control, such as… CONTINUE READING

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