Uncovering network systems within protein structures.

  title={Uncovering network systems within protein structures.},
  author={Lesley H. Greene and Victoria A. Higman},
  journal={Journal of molecular biology},
  volume={334 4},
Traditionally, proteins have been viewed as a construct based on elements of secondary structure and their arrangement in three-dimensional space. In a departure from this perspective we show that protein structures can be modelled as network systems that exhibit small-world, single-scale, and to some degree, scale-free properties. The phenomenological network concept of degrees of separation is applied to three-dimensional protein structure networks and reveals how amino acid residues can be… CONTINUE READING
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