Uncovering glycocalyx mechanosignaling and mechanoremodeling mechanisms

  • Eno E Ebong
  • Published 2014 in
    2014 40th Annual Northeast Bioengineering…

Abstract

The endothelial glycocalyx (GCX) mediates flow-induced nitric oxide signaling and cellular remodeling via its abundant heparan sulfate (HS) component. Until recently, little was known about the ultrastructural details and the activity of the HS core proteins involved in these GCX mediated mechanotransduction events. Here, we study flow regulation of GCX… (More)

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