Uncovering disease-disease relationships through the incomplete human interactome

  title={Uncovering disease-disease relationships through the incomplete human interactome},
  author={J{\"o}rg Menche and Amitabh Sharma and Maksim Kitsak and Susan Dina Ghiassian and Marc Vidal and Joseph Loscalzo and Albert-L{\'a}szl{\'o} Barab{\'a}si},
According to the disease module hypothesis the cellular components associated with a disease segregate in the same neighborhood of the human interactome, the map of biologically relevant molecular interactions. Yet, given the incompleteness of the interactome and the limited knowledge of disease-associated genes, it is not obvious if the available data has sufficient coverage to map out modules associated with each disease. Here we derive mathematical conditions for the identifiability of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.
Showing 1-2 of 2 references

Networks in cell biology

  • M. Buchanan, G. Caldarelli, P. De Los Rios
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…