Uncovering disease-disease relationships through the incomplete interactome

@article{Menche2015UncoveringDR,
  title={Uncovering disease-disease relationships through the incomplete interactome},
  author={J{\"o}rg Menche and Amitabh Sharma and Maksim Kitsak and Susan Dina Ghiassian and Marc Vidal and Joseph Loscalzo and Albert-L{\'a}szl{\'o} Barab{\'a}si},
  journal={Science},
  year={2015},
  volume={347}
}
According to the disease module hypothesis, the cellular components associated with a disease segregate in the same neighborhood of the human interactome, the map of biologically relevant molecular interactions. Yet, given the incompleteness of the interactome and the limited knowledge of disease-associated genes, it is not obvious if the available data have sufficient coverage to map out modules associated with each disease. Here we derive mathematical conditions for the identifiability of… CONTINUE READING

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