Uncovering Enhancer Functions Using the α-Globin Locus

@inproceedings{Vernimmen2014UncoveringEF,
  title={Uncovering Enhancer Functions Using the α-Globin Locus},
  author={Douglas Vernimmen and Alvaro Rada-Iglesias},
  booktitle={PLoS genetics},
  year={2014}
}
Over the last three decades, studies of the α- and β-globin genes clusters have led to elucidation of the general principles of mammalian gene regulation, such as RNA stability, termination of transcription, and, more importantly, the identification of remote regulatory elements. More recently, detailed studies of α-globin regulation, using both mouse and human loci, allowed the dissection of the sequential order in which transcription factors are recruited to the locus during lineage… CONTINUE READING
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