Uncover disease genes by maximizing information flow in the phenome–interactome network

@inproceedings{Chen2011UncoverDG,
  title={Uncover disease genes by maximizing information flow in the phenome–interactome network},
  author={Yong Chen and Tao Jiang and Rui Jiang},
  booktitle={Bioinformatics [ISMB/ECCB]},
  year={2011}
}
MOTIVATION Pinpointing genes that underlie human inherited diseases among candidate genes in susceptibility genetic regions is the primary step towards the understanding of pathogenesis of diseases. Although several probabilistic models have been proposed to prioritize candidate genes using phenotype similarities and protein-protein interactions, no combinatorial approaches have been proposed in the literature. RESULTS We propose the first combinatorial approach for prioritizing candidate… CONTINUE READING
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