Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles


Synaptotagmin I (syt1) is required for normal rates of synaptic vesicle endo- and exocytosis. However, whether the kinetic defects observed during endocytosis in Syt1 knockout neurons are secondary to defective exocytosis or whether syt1 directly regulates the rate of vesicle retrieval remains unknown. To address this question, we sought to dissociate these… (More)
DOI: 10.1038/nn.3013


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