Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

@article{Pei2010UncouplingTD,
  title={Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects},
  author={Lin Pei and Shupeng Li and Min Wang and Mustansir Diwan and Hymie Anisman and Paul N. Fletcher and Jos{\'e} N. Nobrega and Fang Liu},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={1393-1395}
}
We report that coupling between dopamine D1 and D2 receptors was markedly increased in postmortem brain of subjects suffering from major depression. Biochemical analyses revealed that D1 and D2 receptors form heterodimers via a direct protein-protein interaction. Administration of an interfering peptide that disrupts the D1-D2 receptor complex substantially reduced immobility in the forced swim test (FST) without affecting locomotor activity, and decreased escape failures in learned… CONTINUE READING