Uncoupling proteins: the issues from a biochemist point of view.

  title={Uncoupling proteins: the issues from a biochemist point of view.},
  author={Martin Klingenberg and K S Echtay},
  journal={Biochimica et biophysica acta},
  volume={1504 1},
The functional characteristics of uncoupling proteins (UCP) are reviewed, with the main focus on the results with isolated and reconstituted proteins. UCP1 from brown adipose tissue, the paradigm of the UCP subfamily, is treated in more detail. The issues addressed are the role and mechanism of fatty acids, the nucleotide binding, the regulation by pH and the identification by mutagenesis of residues involved in these functions. The transport and regulatory functions of UCP2 and 3 are reviewed… CONTINUE READING
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