Uncoupling proteins: a role in protection against reactive oxygen species--or not?

@article{Cannon2006UncouplingPA,
  title={Uncoupling proteins: a role in protection against reactive oxygen species--or not?},
  author={Barbara A Cannon and Irina G Shabalina and Tatiana V Kramarova and Natasa B Petrovic and Jan Nedergaard},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1757 5-6},
  pages={449-58}
}
A physiological function of the original uncoupling protein, UCP1, is well established: UCP1 is the molecular background for nonshivering thermogenesis. The functions of the "novel" UCPs, UCP2 and UCP3, are still not established. Recent discussions imply that all UCPs may play a role in protection against reactive oxygen species (ROS). Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs… CONTINUE READING

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