Uncoupling protein-3: clues in an ongoing mitochondrial mystery.

  title={Uncoupling protein-3: clues in an ongoing mitochondrial mystery.},
  author={V{\'e}ronic B{\'e}zaire and Erin L. Seifert and M H Harper},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={21 2},
Uncoupling protein (UCP) 3 (UCP3) is a mitochondrial anion carrier protein with highly selective expression in skeletal muscle. Despite a great deal of interest, to date neither its molecular mechanism nor its biochemical and physiological functions are well understood. Based on its high degree of homology to the original UCP (UCP1), early studies examined a role for UCP3 in thermogenesis. However, evidence for such a function is lacking. Recent studies have focused on two distinct, but not… CONTINUE READING