Uncoupling protein-2 protects endothelial function in diet-induced obese mice.

@article{Tian2012UncouplingPP,
  title={Uncoupling protein-2 protects endothelial function in diet-induced obese mice.},
  author={Xiao Yu Tian and Wing Tak Kenneth Wong and Aimin Xu and Ye Lu and Yang Zhang and Li Yang Wang and Wai San Cheang and Yu Wang and Xiao-qiang Yao and Yu Huang},
  journal={Circulation research},
  year={2012},
  volume={110 9},
  pages={
          1211-6
        }
}
RATIONALE Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of UCP2 in endothelial dysfunction associated with diabetes and obesity is unclear. OBJECTIVE UCP2 protects against endothelial dysfunction induced by high-fat diet through inhibition of reactive oxygen species (ROS) production, and subsequent increase of nitric oxide bioavailability… CONTINUE READING

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