Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients.

@article{Sasahara2004UncouplingP2,
  title={Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients.},
  author={Miyoshi Sasahara and Masahiro Nishi and Hiromichi Kawashima and Kazuya Ueda and Setsuya Sakagashira and Hiroto Furuta and Eisaku Matsumoto and Tadashi Hanabusa and Hideyuki Sasaki and Kishio Nanjo},
  journal={Diabetes},
  year={2004},
  volume={53 2},
  pages={482-5}
}
Common uncoupling protein 2 (UCP2) promoter polymorphism -866G/A is reported to be associated with its expression in adipose tissue and the risk of obesity in Caucasians. On the other hand, several studies suggested that UCP2 expression in beta-cells is an important determinant of insulin secretion. In the Japanese population, morbid obesity is very rare, and insulin secretion capacity is relatively low as compared with Caucasians. Because UCP2 would link to insulin secretion and obesity, it… CONTINUE READING

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