Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.

@article{Pecqueur2008UncouplingPC,
  title={Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.},
  author={Claire Pecqueur and Thi Ngoc Ha Bui and Chantal Gelly and Julie Hauchard and C{\'e}line Barbot and Fr{\'e}d{\'e}ric Bouillaud and Daniel Ricquier and Bruno Miroux and Craig B Thompson},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 1},
  pages={
          9-18
        }
}
Uncoupling protein-2 (UCP2) belongs to the mitochondrial carrier family and has been thought to be involved in suppressing mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis. However, we show here that loss of function of UCP2 does not result in a significant increase in ROS production or an increased propensity for cells to undergo senescence in culture. Instead, Ucp2-/- cells display enhanced proliferation associated with a metabolic switch from fatty… CONTINUE READING
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