Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose.


Recent evidence suggests that mitochondrial uncoupling protein 2 (UCP2) in pancreatic beta-cells plays a crucial role in insulin production and secretion. We hypothesized that 2 UCP2 polymorphisms, a -55C/T (Ala55Val) substitution in exon 4 and an exon 8 insertion, would alter the acute insulin response to glucose (AIRg). Subjects were 155 African American… (More)
DOI: 10.1016/j.metabol.2009.02.016

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