Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold.

  title={Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold.},
  author={Balazs Horvath and Claudia D Spies and Gy{\"o}ngyi Horv{\'a}th and Wolfgang J. Kox and Suzanne Miyamoto and S. G. Barry and Craig H Warden and Ingo Bechmann and Sabrina Diano and Jill Heemskerk and Tam{\'a}s L. Horv{\'a}th},
  journal={Biochemical pharmacology},
  volume={64 3},
Abuse of ethanol is a major risk factor in medicine, in part because of its widespread effect on the activity of the central nervous system, including behavior, pain, and temperature sensation. Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis. Its expression in mitochondria of axons and axon terminals of basal forebrain areas suggests that UCP2 may be involved in the regulation of complex neuronal responses to ethanol. We employed a paradigm… CONTINUE READING


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