Uncoupling protein-2 (UCP2): Molecular and genetic studies

  title={Uncoupling protein-2 (UCP2): Molecular and genetic studies},
  author={Daniel Ricquier},
  journal={International Journal of Obesity},
Thermogenesis is associated to oxygen consumption and cellular respiration. This process is coupled to adenosine-diphosphate (ADP) phosphorylation through the existence of a proton gradient across the inner mitochondrial membrane. It was postulated that proton leaks through this membrane would uncouple respiration from adenosine-triphosphate (ATP) synthesis and induce energy dissipation as heat. Such a mechanism was identified in thermogenic brown adipose tissue mitochondria which contain a… CONTINUE READING


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