Uncoupling of the glucagon receptor-adenylate cyclase system by glucagon in cloned differentiated rat hepatocytes.

@article{Reilly1980UncouplingOT,
  title={Uncoupling of the glucagon receptor-adenylate cyclase system by glucagon in cloned differentiated rat hepatocytes.},
  author={Thomas M. Reilly and Suzanne K. Beckner and Melvln Blecher},
  journal={Journal of receptor research},
  year={1980},
  volume={1 2},
  pages={277-311}
}
The ability of glucagon to induce a state of desensitization to glucagon responsiveness has been examined in a cloned line of normal, differentiated, diploid rat hepatocytes (RL-PR-C). These cells, which respond to glucagon with increased production of cyclic AMP, become refractory to further stimulation of cyclic AMP synthesis following a 4 hour exposure period of the cells to the hormone. Refractoriness to glucagon was demonstrated over a wide range of hormone concentrations (10(-12) to 10(-6… CONTINUE READING