Uncoupling of proopiomelanocortin (POMC) fragments is related to self-injury.

  title={Uncoupling of proopiomelanocortin (POMC) fragments is related to self-injury.},
  author={Curt A. Sandman and William P. Hetrick and Dawn M. Talyor and Sylvie Marion and Aleksandra Chicz-Demet},
  volume={21 6},
Proopiomelanocortin (POMC) contains several interesting, behaviorally active peptides. Release patterns of these fragments have been related to bizarre episodes of self-injurious behavior (SIB) among autistic individuals. Moreover, elevation in beta-endorphin (betaE) but not ACTH levels was associated with a positive response to an acutely administered, centrally acting opioid blocker among autistic individuals exhibiting SIB. In the present study, POMC fragments were measured in 12 self… CONTINUE READING