Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue.

@article{Cheng2007UncouplingOO,
  title={Uncoupling of oxidative phosphorylation enables Candida albicans to resist killing by phagocytes and persist in tissue.},
  author={Shaoji Cheng and Cornelius J. Clancy and Zongde Zhang and Binghua Hao and Wei Wang and Kenneth A. Iczkowski and Michael A. Pfaller and Minh Hong Nguyen},
  journal={Cellular microbiology},
  year={2007},
  volume={9 2},
  pages={492-501}
}
After five serial passages of Candida albicans SC5314 through murine spleens by intravenous inoculation, we recovered a respiratory mutant (strain P5) that exhibited reduced colony size, stunted growth in glucose-deficient media, increased oxygen consumption and defective carbohydrate assimilation. Strain P5 was indistinguishable from SC5314 by DNA typing methods, but had a greater concentration of mitochondria by SYTO18 staining. Treatment with various inhibitors demonstrated that strain P5's… CONTINUE READING
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