Uncoupling of local blood flow and metabolism in the hippocampal CA3 in kainic acid-induced limbic seizure status.

@article{Tanaka1990UncouplingOL,
  title={Uncoupling of local blood flow and metabolism in the hippocampal CA3 in kainic acid-induced limbic seizure status.},
  author={Sai‐ichi Tanaka and Kazuhiro Sako and Tatsuya Tanaka and Isamu Nishihara and Yukichi Yonemasu},
  journal={Neuroscience},
  year={1990},
  volume={36 2},
  pages={339-48}
}
Limbic seizure status was induced by microinjection of kainic acid into a unilateral amygdala in rats. Two hours after kainic acid injection, distant neuronal cell damage was produced, especially in the hippocampal CA3 on the kainic acid-injected side. In order to elucidate the mechanism of this neuronal cell damage, local cerebral glucose utilization and local cerebral blood flow were studied by means of an autoradiographic method using [14C]2-deoxyglucose and [14C]iodoantipyrine during kainic… CONTINUE READING

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