Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

@article{Clynes1998UncouplingOI,
  title={Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.},
  author={Raphael Clynes and Claudia Dumitru and Jeffrey V Ravetch},
  journal={Science},
  year={1998},
  volume={279 5353},
  pages={1052-4}
}
The generation of autoantibody and subsequent tissue deposition of immune complexes (IC) is thought to trigger the pathogenic consequences of systemic autoimmune disease. Modulation of the autoantibody response disrupts pathogenesis by preventing the formation of ICs; however, uncoupling IC formation from subsequent inflammatory responses seems unlikely because of the apparent complexity of the IC-triggered inflammatory cascade. However, the disruption of a single gene, which encodes the gamma… CONTINUE READING

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