Uncoupling of flow and metabolism by chloral hydrate: a rat in-vivo autoradiographic study.

@article{Uematsu2009UncouplingOF,
  title={Uncoupling of flow and metabolism by chloral hydrate: a rat in-vivo autoradiographic study.},
  author={Miki Uematsu and Masashi Takasawa and Rie Hosoi and Osamu Inoue},
  journal={Neuroreport},
  year={2009},
  volume={20 3},
  pages={219-22}
}
General anesthesia is commonly used in experiments; however, its effects on cerebral circulation remain unknown. We measured cerebral blood flow using N-isopropyl[methyl 1,3-14C] p-iodoamphetamine (14C-IMP) and glucose utilization using 2-[1-14C] deoxy-D-glucose during general anesthesia with pentobarbital and chloral hydrate as well as conscious controls using rats and in-vivo autoradiography. Although a substantial reduction in 14C-IMP uptake was seen in the pentobarbital group, there was a… CONTINUE READING

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