Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential.

@article{Borgens1995UncouplingHF,
  title={Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential.},
  author={Richard Ben Borgens and Riyi Shi},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={1995},
  volume={203 4},
  pages={456-67}
}
We have shown that unidirectional pumping of Na+ out of the neural tube's luminal fluids in amphibian embryos produces a large potential difference (40-90 mV, lumen negative to the abluminal surface). This transneural tube potential (TNTP) is analogous to the Na+ dependent transepithelial potential (TEP) that exists across surface ectoderm. This TEP is retained in ectoderm after it is internalized when the neural folds fuse to form the neural tube. The TNTP can be markedly reduced for several… CONTINUE READING
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