Uncoupling effect of the general anesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria.

@article{Branca1991UncouplingEO,
  title={Uncoupling effect of the general anesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria.},
  author={Donata Branca and M S Roberti and Ezio Vincenti and Guido Scutari},
  journal={Archives of biochemistry and biophysics},
  year={1991},
  volume={290 2},
  pages={517-21}
}
2,6-Diisopropylphenol, a general anesthetic, was previously reported to reduce the transmembrane electrical potential in isolated rat liver mitochondria without affecting the rate of ATP production. This effect appeared to contrast with the generally accepted chemiosmotic mechanism for oxidative phosphorylation. In this study we further examined the influence of 2,6-diisopropylphenol on the production of ATP by isolated mitochondria and we studied its effect on the permeability of the inner… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…