Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo.

  title={Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo.},
  author={Girish S. Ratnaparkhi and Songtao Jia and Albert J. Courey},
  volume={133 22},
The Rel family transcription factor Dorsal patterns the dorsoventral axis of the Drosophila embryo by activating genes such as twist and snail and repressing genes such as decapentaplegic and zerknüllt. Dorsal represses transcription by recruiting the co-repressor Groucho. However, repression occurs only when Dorsal-binding sites are close to binding sites for other factors that also bind Groucho. The need for additional factors to assist Dorsal in repression may result from the intrinsically… CONTINUE READING
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