Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy.

@article{Crompton2014UncouplingTE,
  title={Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy.},
  author={Joseph G. Crompton and Madhusudhanan Sukumar and Nicholas P. Restifo},
  journal={Immunological reviews},
  year={2014},
  volume={257 1},
  pages={
          264-276
        }
}
  • Joseph G. Crompton, Madhusudhanan Sukumar, Nicholas P. Restifo
  • Published in Immunological reviews 2014
  • Biology, Medicine
  • Adoptive cellular immunotherapy (ACT) is a potentially curative therapy for patients with advanced cancer. Eradication of tumor in mouse models and humans correlates with both a high dose of adoptively transferred cells and cells with a minimally differentiated phenotype that maintain replicative capacity and multipotency. We speculate that response to ACT not only requires transfer of cells with immediate cytolytic effector function to kill the bulk of fast-growing tumor but also transfer of… CONTINUE READING

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