Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells

@inproceedings{Ho2012UncouplingP,
  title={Uncoupling Protein-4 (UCP4) Increases ATP Supply by Interacting with Mitochondrial Complex II in Neuroblastoma Cells},
  author={Philip Ho and Jessica Wing-Man Ho and Ho-Man Tse and Danny Hon-Fai So and David Chi-Wai Yiu and H W Liu and Koon Ho Chan and Michelle Hiu-Wai Kung and David Boyer Ramsden and S E Ho},
  booktitle={PloS one},
  year={2012}
}
Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP(+)), but how UCP4 affects mitochondrial function is unclear. Here we investigated how UCP4 affects mitochondrial bioenergetics in SH-SY5Y cells. Cells stably overexpressing UCP4 exhibited higher oxygen consumption (10.1%, p<0.01), with 20% greater proton leak than vector controls (p<0.01). Increased ATP supply was observed in UCP4-overexpressing cells compared to… CONTINUE READING

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