Uncoupling Dendrite Growth and Patterning: Single-Cell Knockout Analysis of NMDA Receptor 2B

@article{Espinosa2009UncouplingDG,
  title={Uncoupling Dendrite Growth and Patterning: Single-Cell Knockout Analysis of NMDA Receptor 2B},
  author={Juan Sebasti{\'a}n Espinosa and Damian G. Wheeler and Richard W. Tsien and Liqun Luo},
  journal={Neuron},
  year={2009},
  volume={62},
  pages={205-217}
}
N-methyl-D-aspartate receptors (NMDARs) play important functions in neural development. NR2B is the predominant NR2 subunit of NMDAR in the developing brain. Here we use mosaic analysis with double markers (MADM) to knock out NR2B in isolated single cells and analyze its cell-autonomous function in dendrite development. NR2B mutant dentate gyrus granule cells (dGCs) and barrel cortex layer 4 spiny stellate cells (bSCs) have similar dendritic growth rates, total length, and branch number as… CONTINUE READING

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