Uncoupling Caveolae From Intracellular Signaling In Vivo.

  title={Uncoupling Caveolae From Intracellular Signaling In Vivo.},
  author={Jan R Kraehling and Zhengrong Hao and Monica Yunkyung Lee and David J. Vinyard and Heino Vel{\'a}zquez and Xinran Liu and Radu V Stan and Gary W Brudvig and William C Sessa},
  journal={Circulation research},
  volume={118 1},
RATIONALE Caveolin-1 (Cav-1) negatively regulates endothelial nitric oxide (NO) synthase-derived NO production, and this has been mapped to several residues on Cav-1, including F92. Herein, we reasoned that endothelial expression of an F92ACav-1 transgene would let us decipher the mechanisms and relationships between caveolae structure and intracellular… CONTINUE READING