Uncoupling CD21 and CD19 of the B-cell coreceptor.


Complement receptors (CRs) CD21 and CD35 form a coreceptor with CD19 and CD81 on murine B cells that when coligated with the B-cell receptor lowers the threshold of activation by several orders of magnitude. This intrinsic signaling role is thought to explain the impaired humoral immunity of mice bearing deficiency in CRs. However, CRs have additional roles… (More)
DOI: 10.1073/pnas.0903477106


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@article{Barrington2009UncouplingCA, title={Uncoupling CD21 and CD19 of the B-cell coreceptor.}, author={Robert A Barrington and Thomas Schneider and Lisa A. Pitcher and Thorsten R Mempel and Minghe Ma and Natasha S. Barteneva and Michael C. Carroll}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2009}, volume={106 34}, pages={14490-5} }