Uncouplers of oxidative phosphorylation promote derepression of the hexose transport system in cultures of hamster cells.

  title={Uncouplers of oxidative phosphorylation promote derepression of the hexose transport system in cultures of hamster cells.},
  author={Herman M. Kalckar and C W Christopher and Donna B. Ullrey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={76 12},
Long-term (18-24 hr) preincubation of NIL hamster cell cultures with D-glucose or D-glucosamine (both of which repress the hexose transport system) gave rise to a striking loss of the hexose transport system ("super-repression") when cycloheximide was also present in the culture medium. However, if 0.2 mM 2,4-dinitrophenol (DNP) was also present, the cycloheximide-mediated super-repression was prevented. Moreover, the presence of DNP at this low concentration contributed to an increase in… 

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