Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasma membrane-derived vesicles.

@article{Seelenmeyer2008UnconventionalSO,
  title={Unconventional secretion of fibroblast growth factor 2 and galectin-1 does not require shedding of plasma membrane-derived vesicles.},
  author={Claudia Seelenmeyer and Carolin Stegmayer and Walter Nickel},
  journal={FEBS letters},
  year={2008},
  volume={582 9},
  pages={1362-8}
}
Various molecular mechanisms of unconventional secretion of fibroblast growth factor 2 and galectin-1 have been proposed. A non-vesicular pathway that is based on direct translocation across the plasma membrane has been described. In other studies, however, release into the extracellular space of cell-derived vesicles was implicated in both FGF-2 and Gal-1 secretion. Such vesicles were proposed to originate either from plasma membrane shedding or by the release of exosomes. Employing an… CONTINUE READING

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