Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer.

@article{Lee2013UnconventionalRO,
  title={Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer.},
  author={Inkyoung Lee and Sook-Ja Lee and Tong Mook Kang and Gyeong Hoon Kang and Chaehwa Park},
  journal={Cancer research},
  year={2013},
  volume={73 3},
  pages={
          1056-62
        }
}
The constitutive activation of NF-κB is a major event leading to the initiation, development, and progression of cancer. Recently, we showed that the size of preestablished tumors was reduced after the depletion of Kir2.2, an inwardly rectifying potassium channel. To determine the precise mechanism of action of Kir2.2 in the control of tumor growth, we searched for interacting proteins. Notably, NF-κB p65/RelA was identified as a binding partner of Kir2.2 in a yeast two-hybrid analysis. Further… CONTINUE READING
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