Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding.

@article{Backhaus2004UnconventionalPS,
  title={Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding.},
  author={Rafael Backhaus and Christoph Zehe and Sabine Wegehingel and Angelika Kehlenbach and Blanche Schwappach and Walter Nickel},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 9},
  pages={1727-36}
}
Endoplasmic reticulum/Golgi-dependent protein secretion depends on signal peptides that mediate membrane translocation of nascent secretory proteins into the lumen of the endoplasmic reticulum. Classical secretory proteins are transported across the membrane of the endoplasmic reticulum in an unfolded conformation, which is similar to protein import into mitochondria. This process is mediated by Sec61, the protein-conducting channel of the endoplasmic reticulum. Employing both FACS-based in… CONTINUE READING

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