Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding

  title={Unconventional protein secretion: membrane translocation of FGF-2 does not require protein unfolding},
  author={R. Backhaus and Christoph Zehe and S. Wegehingel and A. Kehlenbach and B. Schwappach and W. Nickel},
  journal={Journal of Cell Science},
  pages={1727 - 1736}
  • R. Backhaus, Christoph Zehe, +3 authors W. Nickel
  • Published 2004
  • Biology, Medicine
  • Journal of Cell Science
  • Endoplasmic reticulum/Golgi-dependent protein secretion depends on signal peptides that mediate membrane translocation of nascent secretory proteins into the lumen of the endoplasmic reticulum. Classical secretory proteins are transported across the membrane of the endoplasmic reticulum in an unfolded conformation, which is similar to protein import into mitochondria. This process is mediated by Sec61, the protein-conducting channel of the endoplasmic reticulum. Employing both FACS-based in… CONTINUE READING
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