Unconventional post-translational modifications in immunological signaling

  title={Unconventional post-translational modifications in immunological signaling},
  author={Kerri A. Mowen and Michael W. David},
  journal={Nature Immunology},
The activity of a cell is governed by the signals it receives from the extracellular milieu, which are 'translated' into the appropriate biological output, such as activation, survival, proliferation, migration or differentiation. Signaling pathways are responsible for converting environmental cues into discrete intracellular events. The alteration of existing proteins by post-translational modification (PTM) is a key feature of signal-transduction pathways that allows the modulation of protein… CONTINUE READING