Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.

@article{Bose2004UnconventionalMM,
  title={Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.},
  author={Avirup Bose and Stacey Robida and Paul S. Furcinitti and Anil Kumar Chawla and Kevin Fogarty and Silvia Corvera and Michael P. Czech},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 12},
  pages={
          5447-58
        }
}
Glucose homeostasis is controlled in part by regulation of glucose uptake into muscle and adipose tissue. Intracellular membrane vesicles containing the GLUT4 glucose transporter move towards the cell cortex in response to insulin and then fuse with the plasma membrane. Here we show that the fusion step is retarded by the inhibition of phosphatidylinositol (PI) 3-kinase. Treatment of insulin-stimulated 3T3-L1 adipocytes with the PI 3-kinase inhibitor LY294002 causes the accumulation of GLUT4… CONTINUE READING

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