Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone.

Abstract

Steroids regulate cell proliferation, tissue development, and cell signaling via two pathways: a nuclear receptor mechanism and genome-independent signaling. Sperm activation, egg maturation, and steroid-induced anesthesia are executed via the latter pathway, the key components of which remain unknown. Here, we present characterization of the human sperm… (More)
DOI: 10.1126/science.aad6887

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