Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.

@article{Distler2004UncontrolledEO,
  title={Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.},
  author={Oliver Distler and J{\"o}rg H. W. Distler and Annette Scheid and Till Acker and Astrid Hirth and Janine Rethage and Beat Michel and Renate Erika Gay and Ulf Mueller-Ladner and Marco Matucci-Cerinic and Karl Heinz Plate and Max Gassmann and S. Kirsten Gay},
  journal={Circulation research},
  year={2004},
  volume={95 1},
  pages={109-16}
}
Systemic sclerosis (SSc) skin lesions are characterized by disturbed vessel morphology with enlarged capillaries and an overall reduction in capillary density, suggesting a deregulated, insufficient angiogenic response. It has been postulated that this phenomenon is due to reduced expression of the potent angiogenic factor vascular endothelial growth factor (VEGF). In contrast to this hypothesis, we demonstrate that the expression of both VEGF and its receptors VEGFR-1 and VEGFR-2 is… CONTINUE READING

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